犯罪心理讲述了美国联邦调查局总部下属的行为分析科部门简称BAU中行为分析师们剖析最棘手的案件分析凶手的心理和作案特征并在他们再次施暴前预测出他们的下一步行动协助当地警察捉拿凶手 本季前期拍摄时剧中一贯以来的领头人Hotch因为和编剧的冲突被剧组开除因此只会出现在本季前两集为了弥补主角的离开CBS将引入两名新角色同时把Emily的扮演者Paget Brewster提升为本季常规演员同时Reid母亲的扮演者Jane Lynch也会在十二季回归
Six months have passed since Dr Ogden moved to Buffalo and Det Murdoch is constantly a loggerheads with Dr Francis, her replacement While Insp Brackenreid thinks highly of Francis, who was recruited from Scotland Yard, Murdoch finds him stubborn and unimaginative He also seems to be in no rush to help Murdoch with his latest case where human body body parts were discovered on a riverbank encased in cement A homeless man living in the woods nearby is questioned and released and Murdoch corresponds with Dr Ogden who offers him valuable advice in her letters He also gets help from a retired detective, Malcolm Lamb Murdoch connects his current investigation a rape and murder that had occurred many years before